The region’s macro environment analysis identifies the measures that would improve the investment environment in the region and help to create an effective direct domestic and foreign investment promotion system. Based on the findings of the integrated analysis, in the decision-making stage the investment direction is selected, the implementation of which will allow achieving the stated goal. The alternatives for the implementation of the investment direction are formed. Alternatives are described using the efficiency criteria and are assessed using MCDM1 multi-criteria methods. The article presents the creation of the theoretical model of determination of the investment strategy in the context of sustainable development. The study includes an integrated regional analysis using Vilnius district as an example