Business development is vital for any firms. However, globalization and the rapid development of technologies have made it difficult to find appropriate business partners such as suppliers and customers, and build reciprocal relationships among them, while it simultaneously offers many opportunities. In this contribution, we propose AI-based approach to find plausible candidates of business partners using firm profiles and transactional relationships among them. We employ machine learning techniques to build a prediction model of customer–supplier relationships. We applied our approach to the large amount of actual business data. The results showed that our approach successfully found potential business partners with F-values of about 84% and reciprocity among them with F-values of about 77%. Using our method, we also developed the Web-based system that helps people in actual businesses to find their new business partners. These contribute to developing one’s own business in the complicated, specialized and rapidly changing business environments of recent years