The paper investigates the requirements of users with disabilities and the implications that these tourists have for developing accessible tourism information systems. A series of focus groups and interviews revealed the informational needs of people with disabilities, as well as the relevant technical difficulties involved in addressing these needs. The results indicated that the indispensable requirements include the following: (1) the veto or absolutely minimal prerequisites principle; (2) an indication of holistic accessibility paths; and (3) door-to-door access maps. The technical challenges identified focus on interoperability, content integration and personalization. The paper concludes by demonstrating how the tourism industry can overcome these challenges and address disabled travelers’ needs