This study investigates the role of job expenditure and job control on negative work-home interference according the Effort-Recovery model. In addition, the role of work-home arrangements, as a measure of home control, is investigated. This study concerns higher educated employees who have been graduated from a business university. Working overtime, work-home arrangements and autonomy were significantly related to negative work-home interference giving proof to the Effort-Recovery model. Especially employees who work in the hospitality industry indicated significantly more working overtime and less being positive about the work-home arrangements while these were the most important predictors of negative work-home interference. The results give directions to what HRM policies organizations should pay attention to, to minimize negative work-home interference and its negative consequences among their employees