Debate about information and communication technology, Importance and its role in growth and economic progress of Organization, is one of the most important subjects of economics and economic development. Indeed the driving engine of globalization in the field of culture, politics, economics and society can be considered as a form of ICT that it was very effective in the emerging network society and sharing knowledge between countries. Information technology is changing the marketing process, access to information on political and economic organizations, and technical knowledge of how to change the supply of goods and services. Organizations can use this technology without constraints of time and place and provide better after-sales service. In addition, in electronic banking and shopping facilities, easy payment methods, taxes and government spending and etc. will be effective in attracting customer. In this paper by using Panel Data model, the effect of ICT and e-banking on Growth and Profitability of Banks in Iran during the years of 2004-2009 has been studied. The results of estimating the growth and profitability pattern with regards to ICT and e-banking indices in Iranians banks was positive and statistically significant.